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Effects on Long-Term Treatment Continuation Taking a slower approach to dose increases not only reduces early side effects but also encourages patients to stick with their treatment over the long term

The distinction between IM and subcutaneous is unlikely to be clinically meaningful given the absence of human pharmacokinetic benchmarks for either route

One commenter indicated they had already spent more than the cost of the entire one-time burden estimate in just reviewing the proposed rule

This functional complexity also makes the ankle vulnerable to injuries that can become chronic problems when healing does not proceed optimally